{"id":114,"date":"2011-01-21T19:33:14","date_gmt":"2011-01-21T19:33:14","guid":{"rendered":"http:\/\/whnlive.com\/fatigue\/"},"modified":"2015-12-25T18:30:25","modified_gmt":"2015-12-25T18:30:25","slug":"mechanism","status":"publish","type":"page","link":"https:\/\/whnlive.com\/fatigue\/care\/mechanism\/","title":{"rendered":"Mechanism"},"content":{"rendered":"<!--slice begin--><p><iframe loading=\"lazy\" width=\"420\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/Y9bXNnAqRCk\" frameborder=\"0\" allowfullscreen><\/iframe><\/p>\n<h1>Abstract<\/h1>\n<p>This pre\u00adsen\u00adta\u00adtion seg\u00adment describes the series of effects that lead to the choke mech\u00ada\u00adnism. Basic top\u00adics:<\/p>\n<ul>\n<li>Cel\u00adlu\u00adlar stress event, Trig\u00adgers Na\/K imbal\u00adance, Inflates the cell, lim\u00adits Future Flow, plas\u00adma only, forces anaer\u00ado\u00adbic, and locks stress.<\/li>\n<\/ul>\n<h1>The Vascular Network<\/h1>\n<p>The human vas\u00adcu\u00adlar sys\u00adtem is a net\u00adwork of about 50,000 miles of tubes that car\u00adry blood. This blood con\u00adtin\u00adu\u00adous\u00adly deliv\u00aders oxy\u00adgen and nutri\u00adents to body\u2019s cells.<\/p>\n<p>The health of vas\u00adcu\u00adlar net\u00adwork is crit\u00adi\u00adcal. Any vas\u00adcu\u00adlar fail\u00adure that shuts off blood to cells, suf\u00adfo\u00adcates down\u00adstream cells \u2014 usu\u00adal\u00adly with\u00adin moments.<\/p>\n<p>Vas\u00adcu\u00adlar con\u00addi\u00adtions that lim\u00adit blood flow, reduces the blood sup\u00adply, trig\u00adger cel\u00adlu\u00adlar dis\u00adtress and self preser\u00adva\u00adtion.<\/p>\n<p>Fac\u00adtors that affect vas\u00adcu\u00adlar heath are impor\u00adtant to the entire body.<\/p>\n<h1>Vascular Oxygen Supply<\/h1>\n<p>The vas\u00adcu\u00adlar sys\u00adtem is made of cells that also require nutri\u00adents and oxy\u00adgen. Vas\u00adcu\u00adlar cells expe\u00adri\u00adence blood like a bystander near an inter\u00adstate and watch Oxy\u00adgen rich red blood cells zoom by \u2014 loaded with oxy\u00adgen.<\/p>\n<p>But blood veloc\u00adi\u00adty, and CO2 swap mech\u00ada\u00adnisms pre\u00advent vas\u00adcu\u00adlar cells from access\u00ading RBC bound oxy\u00adgen.<\/p>\n<p>This means that vas\u00adcu\u00adlar cells have live on the oxy\u00adgen from some\u00adplace else. They must use the oxy\u00adgen dis\u00adsolved in bulk flu\u00adid, or plas\u00adma.<\/p>\n<h1>Plasma Oxygen<\/h1>\n<p>Through\u00adout med\u00adical his\u00adto\u00adry, plas\u00adma oxy\u00adgen has been a curios\u00adi\u00adty. Med\u00adical texts rec\u00adog\u00adnize a nor\u00admal con\u00adcen\u00adtra\u00adtion at about 3 ml\/liter, tiny com\u00adpared to that the quan\u00adti\u00adty bound to red blood cells.<\/p>\n<p>But tiny does not mean unim\u00adpor\u00adtant \u2014 this seem\u00ading\u00adly small quan\u00adti\u00adty of oxy\u00adgen keeps the vas\u00adcu\u00adlar sys\u00adtem alive.<\/p>\n<p>Until 1987, every\u00adbody except Man\u00adfred von Ardenne, over\u00adlooked the impor\u00adtance of this oxy\u00adgen.<\/p>\n<p>Even now, it is not con\u00adsid\u00adered a fac\u00adtor in health or dis\u00adease even though noth\u00ading could be fur\u00adther from the truth.<\/p>\n<h1>Plasma Hypoxia<\/h1>\n<p>Plas\u00adma hypox\u00adia is insuf\u00adfi\u00adcient oxy\u00adgen in blood plas\u00adma to main\u00adtain vas\u00adcu\u00adlar cell metab\u00ado\u00adlism.<\/p>\n<p>Con\u00addi\u00adtions that reduce plas\u00adma oxy\u00adgen below a crit\u00adi\u00adcal lev\u00adel, can dam\u00adage the vas\u00adcu\u00adlar sys\u00adtem, like the absence of oxy\u00adgen dam\u00adages any cell.<\/p>\n<p>One of the hid\u00adden effects of stress is res\u00adpi\u00adra\u00adto\u00adry com\u00adpen\u00adsa\u00adtion which decreas\u00ades the amount of oxy\u00adgen dis\u00adsolved in plas\u00adma.<\/p>\n<h1>Flow And Concentration<\/h1>\n<p>There are two known fac\u00adtors that gov\u00adern usable oxy\u00adgen avail\u00adable to vas\u00adcu\u00adlar cells, flow and con\u00adcen\u00adtra\u00adtion.<\/p>\n<p>Flow is the vol\u00adume of plas\u00adma that comes in con\u00adtact with vas\u00adcu\u00adlar cells while con\u00adcen\u00adtra\u00adtion is the total amount of dis\u00adsolved oxy\u00adgen.<\/p>\n<h2>Concentration Variables<\/h2>\n<p>Increas\u00ades in res\u00adpi\u00adra\u00adto\u00adry tur\u00adbu\u00adlence, like breath\u00ading hard, increase sol\u00adu\u00adble oxy\u00adgen lev\u00adels; while shal\u00adlow breath, reduce lev\u00adels.<\/p>\n<p>Dis\u00adsolved solids, like salt, and meta\u00adbol\u00adic waste, reduce oxy\u00adgen sol\u00adu\u00adbil\u00adi\u00adty. <a href=\"http:\/\/www.engineeringtoolbox.com\/oxygen-solubility-water-d_841.html\">Sea water<\/a> holds 25% less oxy\u00adgen than fresh water, and blood plas\u00adma holds 43% less oxy\u00adgen than sea water.<\/p>\n<p>Con\u00addi\u00adtions that increase plas\u00adma-solutes, or tox\u00adins, decrease plas\u00adma oxy\u00adgen lev\u00adels.<\/p>\n<p>This is the hid\u00adden con\u00adnec\u00adtion between blood tox\u00adins, and the vas\u00adcu\u00adlar sys\u00adtem. Plas\u00adma tox\u00adins reduce sol\u00adu\u00adble oxy\u00adgen, and there\u00adfore reduce vital\u00adi\u00adty of vas\u00adcu\u00adlar tis\u00adsue.<\/p>\n<h2>Flow Variables<\/h2>\n<p>Blood is not water \u2014 it is a col\u00adloidal sus\u00adpen\u00adsion gov\u00aderned by elec\u00adtro\u00adsta\u00adt\u00adic repul\u00adsive forces. Sus\u00adpend\u00aded par\u00adti\u00adcles, like blood cells, must have enough elec\u00adtri\u00adal ener\u00adgy to repel each oth\u00ader, oth\u00ader\u00adwise they form clumps that clog the vas\u00adcu\u00adlar sys\u00adtem.<\/p>\n<p>When clumps clog nar\u00adrow\u00ading vas\u00adcu\u00adlar fun\u00adnels, <a href=\"http:\/\/en.wikipedia.org\/wiki\/Arteriole\">arte\u00adri\u00adoles<\/a> clog, flow stops, and down\u00adstream tis\u00adsue suf\u00adfo\u00adcates after oxy\u00adgen is used up. This caus\u00ades cel\u00adlu\u00adlar hypox\u00adia, which trans\u00adforms sludge blood, into a destruc\u00adtive vas\u00adcu\u00adlar inflam\u00adma\u00adtion.<\/p>\n<h1>Vascular Chokes<\/h1>\n<p>When the vas\u00adcu\u00adlar inner skin, or endothe\u00adli\u00adum, becomes oxy\u00adgen deprived, ener\u00adgy metab\u00ado\u00adlism fail\u00adure dis\u00adrupts sodi\u00adum potas\u00adsi\u00adum ion exchange, and these cells accu\u00admu\u00adlate sodi\u00adum, which caus\u00ades them to bloat. Bloat\u00ading reduces the vas\u00adcu\u00adlar diam\u00ade\u00adter, and lim\u00adits flow.<\/p>\n<p>The diam\u00ade\u00adter of a healthy cap\u00adil\u00adlary is small\u00ader than a healthy red blood cell so that blood cells must bend or fold to go through cap\u00adil\u00adlar\u00adies. Bloat\u00ading lim\u00adits flow to plas\u00adma flu\u00adid, and per\u00adhaps red blood cells that may shrink to avoid clog\u00adging the cap\u00adil\u00adlary.<\/p>\n<h1>Stuck Chokes<\/h1>\n<p>Chokes are a stuck effect because the oxy\u00adgen required to requred to to release them can\u00adnot arrive because the pipe is well \u2014 choked.<\/p>\n<p>Man\u00adfred von Ardenne devel\u00adoped a sys\u00adtem for releas\u00ading these chokes, we will talk more about that lat\u00ader.<\/p>\n<p>Log\u00adi\u00adcal\u00adly, the low\u00adest con\u00adcen\u00adtra\u00adtion of oxy\u00adgen at the very end of the pipe. In the vas\u00adcu\u00adlar sys\u00adtem, this is at the venous end of the cap\u00adil\u00adlar\u00adies, just before the blood starts the return jour\u00adney to the heart.<\/p>\n<p>Ardenne and Leowe, dis\u00adcov\u00adered chokes exact\u00adly here, at the area of low\u00adest oxy\u00adgen con\u00adcen\u00adtra\u00adtion. The chokes were small enough to lim\u00adit blood flow, but big enough to allow enough plas\u00adma to pass.<\/p>\n<p>This was the mag\u00adic recipe for stuck. It was enough to keep the tis\u00adsue alive, but not enough to thrive \u2014 Stuck cell stress.<\/p>\n<h1>Cell Distress<\/h1>\n<p>Body cells fed by the cap\u00adil\u00adlar\u00adies enter pro\u00adgres\u00adsive process of dis\u00adtress after cap\u00adil\u00adlar\u00adies choke.<\/p>\n<p>Reduced diam\u00ade\u00adter forces these cells to sur\u00advive on plas\u00adma, which still fits through reduced diam\u00ade\u00adter. Plas\u00adma car\u00adries glu\u00adcose, so cells switch to anaer\u00ado\u00adbic or ener\u00adgy pow\u00ader to sur\u00advive.<\/p>\n<p>Dis\u00adtress pro\u00adgress\u00ades as body cell:<\/p>\n<ul>\n<li>Ener\u00adgy decreas\u00ades from 19 to 1, with\u00adout oxy\u00adgen;<\/li>\n<li>So per\u00adfor\u00admance decreas\u00ades by the same;<\/li>\n<li>Anaer\u00ado\u00adbic cells stop pro\u00adduc\u00ading car\u00adbon diox\u00adide<\/li>\n<li>So cap\u00adil\u00adlar\u00adies valves remain shut;<\/li>\n<li>Anaer\u00ado\u00adbic cells pro\u00adduce acids;<\/li>\n<li>so acids accu\u00admu\u00adlate in the region,<\/li>\n<li>and the area becomes per\u00adma\u00adnent\u00adly acidic;<\/li>\n<li>and the area remains per\u00adma\u00adnent\u00adly dis\u00adtressed.<\/li>\n<\/ul>\n<h1>Distress Accumulates<\/h1>\n<p>These events cre\u00adates a local weak\u00adness, any\u00adwhere, and even\u00adtu\u00adal\u00adly every\u00adwhere in the body when they pile up.<\/p>\n<p>The role and loca\u00adtion of each dis\u00adtressed area deter\u00admines effect. Cell weak\u00adness erodes per\u00adfor\u00admance and acidic waste caus\u00ades irri\u00adta\u00adtion, and local pH imbal\u00adance.<\/p>\n<p>As more of the body enters dis\u00adtress, vital\u00adi\u00adty decreas\u00ades, and health issues emerge.<\/p>\n<p>Dis\u00adtressed tis\u00adsue:<\/p>\n<ul>\n<li>In mus\u00adcle is sore and weak;<\/li>\n<li>In the brain caus\u00ades motor or cog\u00adni\u00adtive dys\u00adfunc\u00adtion;<\/li>\n<li>In immune sys\u00adtem incras\u00ades infec\u00adtion vul\u00adner\u00ada\u00adbil\u00adi\u00adty;<\/li>\n<li>and so on.<\/li>\n<\/ul>\n<p>Large amounts of dis\u00adtressed tis\u00adsue cre\u00adate body-wide effects which inter\u00adfere with glu\u00adcose, pH and oth\u00ader reg\u00adu\u00adla\u00adto\u00adry sys\u00adtems. We will address these effects lat\u00ader.<\/p>\n<h1>Long Term Distress<\/h1>\n<p>These dis\u00adtress effects from cap\u00adil\u00adlary chokes tend to be per\u00adma\u00adnent because the meta\u00adbol\u00adic cir\u00adcum\u00adstances which reverse them rarely occur.<\/p>\n<p>Remem\u00adber plas\u00adma oxy\u00adgen we talked about ear\u00adli\u00ader?<\/p>\n<p>In the next sec\u00adtion we will explain how to use it to release tis\u00adsue dis\u00adtress.<\/p>\n<h1>References<\/h1>\n<p><a href=\"http:\/\/www2.estrellamountain.edu\/faculty\/farabee\/biobk\/BioBookcircSYS.html\">http:\/\/www2.estrellamountain.edu\/faculty\/farabee\/biobk\/BioBookcircSYS.html<\/a><\/p>\n<p><a href=\"http:\/\/www2.estrellamountain.edu\/faculty\/farabee\/biobk\/BioBookcircSYS.html\">http:\/\/faculty.stcc.edu\/AandP\/AP\/imagesAP2\/bloodvessels\/capreal.gif<\/a><\/p>\n<p><a href=\"http:\/\/www.capillarycirculation.com\/CapillaryEchange.html\">http:\/\/www.capillarycirculation.com\/CapillaryEchange.html<\/a><\/p>\n<h1>More Information<\/h1>\n<p>The fol\u00adlow\u00ading parts of this pre\u00adsen\u00adta\u00adtion pro\u00advide more detailed infor\u00adma\u00adtion regard\u00ading phys\u00adi\u00adol\u00ado\u00adgy, his\u00adto\u00adry and much more.<\/p>\n<p>We have ded\u00adi\u00adcat\u00aded an entire web site to these sys\u00adtems. Go to whnlive.com. Hov\u00ader over the Tech\u00adnol\u00ado\u00adgy Menu, and click the Alti\u00adtude Con\u00adtrast menu item to access this site.<\/p>\n<!--slice end-->","protected":false},"excerpt":{"rendered":"<p>Abstract This pre\u00adsen\u00adta\u00adtion seg\u00adment describes the series of effects that lead to the choke mech\u00ada\u00adnism. Basic top\u00adics: Cel\u00adlu\u00adlar stress event, Trig\u00adgers Na\/K imbal\u00adance, Inflates the cell, lim\u00adits Future Flow, plas\u00adma only, forces anaer\u00ado\u00adbic, and locks stress. The Vas\u00adcu\u00adlar Net\u00adwork The human vas\u00adcu\u00adlar sys\u00adtem is a net\u00adwork of about 50,000 miles of tubes that car\u00adry blood. \u2026 <\/p>\n<p><a class=\"more-link btn\" href=\"https:\/\/whnlive.com\/fatigue\/care\/mechanism\/\">Con\u00adtin\u00adue read\u00ading<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":11,"menu_order":1,"comment_status":"open","ping_status":"open","template":"","meta":{"wp_typography_post_enhancements_disabled":false,"footnotes":""},"class_list":["post-114","page","type-page","status-publish","hentry","nodate","item-wrap"],"_links":{"self":[{"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/pages\/114","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/comments?post=114"}],"version-history":[{"count":0,"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/pages\/114\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/pages\/11"}],"wp:attachment":[{"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/media?parent=114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}