{"id":30,"date":"2010-12-27T14:01:00","date_gmt":"2010-12-27T14:01:00","guid":{"rendered":"http:\/\/whnlive.com\/fatigue\/"},"modified":"2010-12-27T14:01:00","modified_gmt":"2010-12-27T14:01:00","slug":"cellular-hypoxia","status":"publish","type":"page","link":"https:\/\/whnlive.com\/fatigue\/cause\/cellular-hypoxia\/","title":{"rendered":"Cellular Hypoxia"},"content":{"rendered":"

Anaer\u00ado\u00adbic metab\u00ado\u00adlism occurs when the oxy\u00adgen sup\u00adply is unable to deliv\u00ader enough oxy\u00adgen to main\u00adtain aer\u00ado\u00adbic ener\u00adgy pro\u00adduc\u00adtion.  It is a sup\u00adply ver\u00adsus demand sys\u00adtem. See Cause for oth\u00ader fac\u00adtors<\/a>.<\/p>\n

Demand exceeds sup\u00adply when either:<\/p>\n

    \n
  1. Burst Demand<\/strong> occurs when there is a tem\u00adpo\u00adrary demand increase that exceeds oxy\u00adgen sup\u00adply \u2014 under short term burst-exer\u00adtion con\u00addi\u00adtions;<\/li>\n
  2. Cel\u00adlu\u00adlar Hypox\u00adia<\/strong> occurs when there is pro\u00adlonged defi\u00adcien\u00adcy due to dys\u00adfunc\u00adtion of the oxy\u00adgen deliv\u00adery, or nutri\u00adent sub\u00adstrate required to main\u00adtain aer\u00ado\u00adbic metab\u00ado\u00adlism becomes durably deplete.<\/li>\n<\/ol>\n

    Sus\u00adtained Cel\u00adlu\u00adlar Hypox\u00adia <\/a>forces cells to oper\u00adate long term anaer\u00ado\u00adbic state, and often part of the process that trig\u00adgers Anaer\u00ado\u00adbic Lock<\/a> con\u00addi\u00adtion.<\/p>\n

    A demand con\u00addi\u00adtion that over\u00adwhelms the pri\u00adma\u00adry and sec\u00adondary sys\u00adtem reserves may cre\u00adate durable cel\u00adlu\u00adlar hypox\u00adia by trig\u00adger\u00ading inflam\u00adma\u00adtion <\/a>in cells that line the vas\u00adcu\u00adlar sys\u00adtem, endothe\u00adli\u00adum<\/a>.   Cel\u00adlu\u00adlar inflam\u00adma\u00adtion occurs when cel\u00adlu\u00adlar sodi\u00adum replaces potas\u00adsi\u00adum, result\u00ading in enlarged regions of polar\u00adized water around sodi\u00adum ions, which in turn com\u00adpel the cell to absorb water inflate.<\/p>\n

    The infla\u00adtion reduces the diam\u00ade\u00adter of the cap\u00adil\u00adlary and lim\u00adits or pre\u00advents pas\u00adsage of ery\u00adthro\u00adcytes<\/a>, red blood cells, through the cap\u00adil\u00adlary.  Lim\u00adit\u00aded ery\u00adthro\u00adcytes, lim\u00adit oxy\u00adgen, which is need\u00aded to reverse the inflam\u00adma\u00adtion, so the con\u00addi\u00adtion remains fixed \u2014 and cel\u00adlu\u00adlar hypox\u00adia becomes durable.<\/p>\n

    Durable hypox\u00adia occurs when a hypox\u00adic or stress episode trig\u00adgers oth\u00ader effects, cap\u00adil\u00adlary choke mech\u00ada\u00adnism (Ardenne)<\/a>,  that inhibits the oxy\u00adgen deliv\u00adery process in an unre\u00adcov\u00ader\u00adable (under nor\u00admal metab\u00ado\u00adlism).  This effect is ful\u00adly described in Chapter\u20111: Oxy\u00adgen Mul\u00adti\u00adstep Ther\u00ada\u00adpy, Ardenne<\/a>.<\/p>\n

    The durable nature of the cap\u00adil\u00adlary choke makes it a dom\u00adi\u00adnant fac\u00adtor in all fatigue and acid relat\u00aded dys\u00adfunc\u00adtions because it cre\u00adates a durable block\u00adage to blood flow and oxy\u00adgen deliv\u00adery.<\/p>\n

    This author asserts it is a dom\u00adi\u00adnant cause of Anaer\u00ado\u00adbic Lock<\/a>.<\/p>\n