{"id":39,"date":"2010-12-27T14:16:53","date_gmt":"2010-12-27T14:16:53","guid":{"rendered":"http:\/\/whnlive.com\/fatigue\/"},"modified":"2010-12-27T14:16:53","modified_gmt":"2010-12-27T14:16:53","slug":"ph-dysregulation","status":"publish","type":"page","link":"https:\/\/whnlive.com\/fatigue\/cause\/ph-dysregulation\/","title":{"rendered":"pH Dysregulation"},"content":{"rendered":"<!--slice begin--><p>Nor\u00admal oper\u00ada\u00adtion of the Kre\u00adb\u2019s Cycle pro\u00adduces CO2 as a byprod\u00aduct.  When the Kre\u00adb\u2019s is inter\u00adrupt\u00aded, the absence of CO2 cre\u00adates defi\u00adcien\u00adcy, and the defi\u00adcien\u00adcy inter\u00adferes with both sides of the pH bal\u00adance sys\u00adtems:<\/p>\n<ul>\n<li> CO2 res\u00adpi\u00adra\u00adtion via Car\u00adbon\u00adic acid through the lungs is the dom\u00adi\u00adnant <strong><em>acid con\u00adtrol<\/em><\/strong> mech\u00ada\u00adnism;<\/li>\n<li> And Bicar\u00adbon\u00adate through the kid\u00adneys, is the dom\u00adi\u00adnant <strong><em>alka\u00adli con\u00adtrol<\/em><\/strong> mech\u00ada\u00adnism;<\/li>\n<li><a href=\"http:\/\/whnlive.com\/fatigue\/cause\/\">See Cause for oth\u00ader fac\u00adtors<\/a>.<\/li>\n<\/ul>\n<p>A defi\u00adcien\u00adcy in CO2 pro\u00adduc\u00adtion can adverse\u00adly affect both both acid and alka\u00adli bal\u00adance sys\u00adtems. &nbsp;This dys\u00adfunc\u00adtion nor\u00admal\u00adly occurs when tis\u00adsues tend to anaer\u00ado\u00adbic metab\u00ado\u00adlism, result\u00ading in ele\u00advat\u00aded lac\u00adtic acid relat\u00aded acids, H+, etc.<\/p>\n<p>So there are mul\u00adti\u00adple con\u00adcur\u00adrent effects which cas\u00adcade into suc\u00adces\u00adsive stages of pH dys\u00adreg\u00adu\u00adla\u00adtion, depend\u00ading on the com\u00adbi\u00adna\u00adtion of deplet\u00aded sub\u00adstrates:<\/p>\n<ol>\n<li>Dis\u00adrup\u00adtion in res\u00adpi\u00adra\u00adto\u00adry pH from car\u00adbon\u00adic &amp; bicar\u00adbon\u00adate bal\u00adance;<\/li>\n<li>Ele\u00advat\u00aded lev\u00adels in lac\u00adtic acid relat\u00aded acids;<\/li>\n<li>Com\u00adpen\u00adsato\u00adry&nbsp;deple\u00adtion in sec\u00adondary oxi\u00adda\u00adtion agents which\n<ul>\n<li> Chlo\u00adride (Depletes Stom\u00adach Acid \/ HCL)<\/li>\n<li> Chalco\u00adgens: Sul\u00adfur \/ Sele\u00adni\u00adum<\/li>\n<li> SO4 \/ NO3<\/li>\n<\/ul>\n<\/li>\n<li><a href=\"http:\/\/en.wikipedia.org\/wiki\/B_vitamin\">B Vit\u00ada\u00admin<\/a> Deple\u00adtion;<\/li>\n<li>Con\u00adtri\u00adbu\u00adtion to the <a href=\"http:\/\/en.wikipedia.org\/wiki\/Bohr_effect\">Bohr Effect<\/a> which decreas\u00ades oxy\u00adgen trans\u00adport; which fur\u00adther con\u00adtributes to <a href=\"http:\/\/whnlive.com\/fatigue\/cause\/cellular-hypoxia\/\">Cel\u00adlu\u00adlar Hypox\u00adia<\/a>;<\/li>\n<li>Appear\u00adance of mul\u00adti\u00adple res\u00adpi\u00adra\u00adto\u00adry imbal\u00adances which man\u00adi\u00adfest var\u00adi\u00adous com\u00adbi\u00adna\u00adtions of respiratory\/metabolic acidosis\/alkalosis.<\/li>\n<\/ol>\n<p>This matrix of effects inter\u00adferes with acid-base home\u00adosta\u00adsis and can result in diverse set of dys\u00adreg\u00adu\u00adla\u00adtion effects, depend\u00ading on the specifics reserves and deple\u00adtions of sec\u00adondary acid-alka\u00adli sub\u00adstrates. &nbsp;<a href=\"http:\/\/en.wikipedia.org\/wiki\/Acid-base_homeostasis\">See acid-base home\u00adosta\u00adsis<\/a>.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/upload.wikimedia.org\/wikipedia\/commons\/1\/18\/Acid-base_nomogram.svg\" alt width=\"320\" height=\"240\"><\/p>\n<!--slice end-->","protected":false},"excerpt":{"rendered":"<p>Nor\u00admal oper\u00ada\u00adtion of the Kre\u00adb\u2019s Cycle pro\u00adduces CO2 as a byprod\u00aduct. When the Kre\u00adb\u2019s is inter\u00adrupt\u00aded, the absence of CO2 cre\u00adates defi\u00adcien\u00adcy, and the defi\u00adcien\u00adcy inter\u00adferes with both sides of the pH bal\u00adance sys\u00adtems: CO2 res\u00adpi\u00adra\u00adtion via Car\u00adbon\u00adic acid through the lungs is the dom\u00adi\u00adnant acid con\u00adtrol mech\u00ada\u00adnism; And Bicar\u00adbon\u00adate through the kid\u00adneys, is the \u2026 <\/p>\n<p><a class=\"more-link btn\" href=\"https:\/\/whnlive.com\/fatigue\/cause\/ph-dysregulation\/\">Con\u00adtin\u00adue read\u00ading<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":9,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"wp_typography_post_enhancements_disabled":false,"footnotes":""},"class_list":["post-39","page","type-page","status-publish","hentry","nodate","item-wrap"],"_links":{"self":[{"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/pages\/39","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/comments?post=39"}],"version-history":[{"count":0,"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/pages\/39\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/pages\/9"}],"wp:attachment":[{"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/media?parent=39"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}