{"id":48,"date":"2010-12-27T14:48:00","date_gmt":"2010-12-27T14:48:00","guid":{"rendered":"http:\/\/whnlive.com\/fatigue\/"},"modified":"2010-12-27T14:48:00","modified_gmt":"2010-12-27T14:48:00","slug":"anaerobic-lock","status":"publish","type":"page","link":"https:\/\/whnlive.com\/fatigue\/cause\/anaerobic-lock\/","title":{"rendered":"Anaerobic Lock"},"content":{"rendered":"<!--slice begin--><p><strong>Anaer\u00ado\u00adbic Lock<\/strong> \u2014 is a pro\u00adlonged meta\u00adbol\u00adic con\u00addi\u00adtion where cells are forced to depend anaer\u00ado\u00adbic gly\u00adcol\u00ady\u00adsis for ener\u00adgy pro\u00adduc\u00adtion. &nbsp;See <a href=\"http:\/\/whnlive.com\/fatigue\/cause\/\">Cause<\/a> for more fac\u00adtors.<\/p>\n<p>This is usu\u00adal\u00adly due to fac\u00adtors which inhib\u00adit oxy\u00adgen deliv\u00adery to the cells includ\u00ading one or more dys\u00adfunc\u00adtions:<\/p>\n<ul>\n<li><a href=\"http:\/\/en.wikipedia.org\/wiki\/Hematology\">hemo\u00adto\u00adlog\u00adi\u00adcal<\/a><\/li>\n<li><a href=\"http:\/\/en.wikipedia.org\/wiki\/Circulatory_system\">cir\u00adcu\u00adla\u00adto\u00adry<\/a><\/li>\n<li><a href=\"http:\/\/en.wikipedia.org\/wiki\/Oxygen_transport#Oxygen_transport\">oxy\u00adgen trans\u00adport<\/a><\/li>\n<\/ul>\n<p>Absence of oxy\u00adgen forces cells to oper\u00adate and sur\u00advive using glu\u00adcose only, or <a href=\"http:\/\/en.wikipedia.org\/wiki\/Anaerobic_glycolysis\">anaer\u00ado\u00adbic gly\u00adcol\u00ady\u00adsis<\/a>. &nbsp;<a href=\"http:\/\/en.wikipedia.org\/wiki\/Aerobic_metabolism\">Aer\u00ado\u00adbic metab\u00ado\u00adlism<\/a> yields 38 ATP\/glucose while <a href=\"http:\/\/en.wikipedia.org\/wiki\/Anaerobic_Respiration\">Anaer\u00ado\u00adbic res\u00adpi\u00adra\u00adtion<\/a> (absent oxy\u00adgen) results in 2 ATP\/Glucose.<\/p>\n<p>Pro\u00adlonged use of the anaer\u00ado\u00adbic gly\u00adcol\u00ady\u00adsis for ener\u00adgy pro\u00adduc\u00adtion caus\u00ades mul\u00adti\u00adple adverse local and sys\u00adtemic effects:<\/p>\n<ul>\n<li><strong>Reduced cel\u00adlu\u00adlar vital\u00adi\u00adty<\/strong> 95% less ener\u00adgy avail\u00adable to per\u00adform cel\u00adlu\u00adlar func\u00adtions;<\/li>\n<li><strong>Glu\u00adcose Dys\u00adreg\u00adu\u00adla\u00adtion:<\/strong>\n<ul>\n<li><strong><\/strong><a href=\"http:\/\/en.wikipedia.org\/wiki\/Hypoglycemia\">hypo\u00adglycemia <\/a>when com\u00adbined <a href=\"http:\/\/en.wikipedia.org\/wiki\/Gluconeogenesis\">glu\u00adco\u00adneogeni\u00adsis<\/a> sub\u00adstrate deple\u00adtion<\/li>\n<li><a href=\"http:\/\/en.wikipedia.org\/wiki\/Hyperglycemia\">hyper\u00adglycemia <\/a>when com\u00adbined with oth\u00ader glu\u00adcose con\u00adtrol dys\u00adfunc\u00adtions;<\/li>\n<\/ul>\n<\/li>\n<li><strong>Under-per\u00adfor\u00admance of organ and mus\u00adcu\u00adlar sys\u00adtems<\/strong> from insuf\u00adfi\u00adcient ener\u00adgy;<\/li>\n<li><strong>Local Dis\u00adcom\u00adfort<\/strong> from Local Aci\u00addo\u00adsis from local accu\u00admu\u00adla\u00adtion of over pro\u00adduc\u00adtion of meta\u00adbol\u00adic acids (lac\u00adtic acid);<\/li>\n<li><strong>Decreased Pathogen Resis\u00adtance<\/strong> where dis\u00adease organ\u00adisms attack ener\u00adgy deplete cells resid\u00ading in an acidic local envi\u00adron\u00adment;<\/li>\n<li><strong>Sys\u00adtemic Aci\u00addo\u00adsis<\/strong> con\u00adtri\u00adbu\u00adtion when large per\u00adcent\u00adage of metab\u00ado\u00adlism is depen\u00addent on anaer\u00ado\u00adbic gly\u00adcol\u00ady\u00adsis over\u00adwhelm acid trans\u00adport;<\/li>\n<li><strong>Nutri\u00adent Deple\u00adtion<\/strong> when the liv\u00ader is forced to over-uti\u00adlize&nbsp;<a href=\"http:\/\/en.wikipedia.org\/wiki\/Gluconeogenesis\">glu\u00adco\u00adneogeni\u00adsis<\/a> \/ <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cori_cycle\">Cori Cycle<\/a>;<\/li>\n<li><strong><a href=\"http:\/\/whnlive.com\/fatigue\/cause\/ph-dysregulation\/\">pH Dys\u00adreg\u00adu\u00adla\u00adtion<\/a><\/strong> \u2014 result\u00ading from insuf\u00adfi\u00adcient Car\u00adbon Diox\u00adide Pro\u00adduc\u00adtion lim\u00adit\u00ading both Car\u00adbon\u00adic acid and bicar\u00adbon\u00adate avail\u00adabil\u00adi\u00adty.<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/upload.wikimedia.org\/wikipedia\/commons\/7\/74\/CellRespiration.svg\" alt width=\"320\" height=\"240\"><br>\n<img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/upload.wikimedia.org\/wikipedia\/commons\/1\/18\/Acid-base_nomogram.svg\" alt width=\"320\" height=\"240\"><\/p>\n<!--slice end-->","protected":false},"excerpt":{"rendered":"<p>Anaer\u00ado\u00adbic Lock \u2014 is a pro\u00adlonged meta\u00adbol\u00adic con\u00addi\u00adtion where cells are forced to depend anaer\u00ado\u00adbic gly\u00adcol\u00ady\u00adsis for ener\u00adgy pro\u00adduc\u00adtion. &nbsp;See Cause for more fac\u00adtors. This is usu\u00adal\u00adly due to fac\u00adtors which inhib\u00adit oxy\u00adgen deliv\u00adery to the cells includ\u00ading one or more dys\u00adfunc\u00adtions: hemo\u00adto\u00adlog\u00adi\u00adcal cir\u00adcu\u00adla\u00adto\u00adry oxy\u00adgen trans\u00adport Absence of oxy\u00adgen forces cells to oper\u00adate and sur\u00advive \u2026 <\/p>\n<p><a class=\"more-link btn\" href=\"https:\/\/whnlive.com\/fatigue\/cause\/anaerobic-lock\/\">Con\u00adtin\u00adue read\u00ading<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":9,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"wp_typography_post_enhancements_disabled":false,"footnotes":""},"class_list":["post-48","page","type-page","status-publish","hentry","nodate","item-wrap"],"_links":{"self":[{"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/pages\/48","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/comments?post=48"}],"version-history":[{"count":0,"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/pages\/48\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/pages\/9"}],"wp:attachment":[{"href":"https:\/\/whnlive.com\/fatigue\/wp-json\/wp\/v2\/media?parent=48"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}