Anaerobic Lock

Anaer­o­bic Lock — is a pro­longed meta­bol­ic con­di­tion where cells are forced to depend anaer­o­bic gly­col­y­sis for ener­gy pro­duc­tion.  See Cause for more fac­tors.

This is usu­al­ly due to fac­tors which inhib­it oxy­gen deliv­ery to the cells includ­ing one or more dys­func­tions:

• hemo­to­log­i­cal
• cir­cu­la­to­ry
• oxy­gen trans­port

Absence of oxy­gen forces cells to oper­ate and sur­vive using glu­cose only, or anaer­o­bic gly­col­y­sis.  Aer­o­bic metab­o­lism yields 38 ATP/glucose while Anaer­o­bic res­pi­ra­tion (absent oxy­gen) results in 2 ATP/Glucose.

Pro­longed use of the anaer­o­bic gly­col­y­sis for ener­gy pro­duc­tion caus­es mul­ti­ple adverse local and sys­temic effects:

• Reduced cel­lu­lar vital­i­ty 95% less ener­gy avail­able to per­form cel­lu­lar func­tions;
• Glu­cose Dys­reg­u­la­tion:
  • hypo­glycemia when com­bined glu­co­neogeni­sis sub­strate deple­tion
  • hyper­glycemia when com­bined with oth­er glu­cose con­trol dys­func­tions;
• Under-per­for­mance of organ and mus­cu­lar sys­tems from insuf­fi­cient ener­gy;
• Local Dis­com­fort from Local Aci­do­sis from local accu­mu­la­tion of over pro­duc­tion of meta­bol­ic acids (lac­tic acid);
• Decreased Pathogen Resis­tance where dis­ease organ­isms attack ener­gy deplete cells resid­ing in an acidic local envi­ron­ment;
• Sys­temic Aci­do­sis con­tri­bu­tion when large per­cent­age of metab­o­lism is depen­dent on anaer­o­bic gly­col­y­sis over­whelm acid trans­port;
• Nutri­ent Deple­tion when the liv­er is forced to over-uti­lize glu­co­neogeni­sis / Cori Cycle;
• pH Dys­reg­u­la­tion — result­ing from insuf­fi­cient Car­bon Diox­ide Pro­duc­tion lim­it­ing both Car­bon­ic acid and bicar­bon­ate avail­abil­i­ty.