Return to Cause

Anaerobic Lock

Anaerobic Lock – is a prolonged metabolic condition where cells are forced to depend anaerobic glycolysis for energy production.  See Cause for more factors.

This is usually due to factors which inhibit oxygen delivery to the cells including one or more dysfunctions:

Absence of oxygen forces cells to operate and survive using glucose only, or anaerobic glycolysis.  Aerobic metabolism yields 38 ATP/glucose while Anaerobic respiration (absent oxygen) results in 2 ATP/Glucose.

Prolonged use of the anaerobic glycolysis for energy production causes multiple adverse local and systemic effects:

  • Reduced cellular vitality 95% less energy available to perform cellular functions;
  • Glucose Dysregulation:
  • Under-performance of organ and muscular systems from insufficient energy;
  • Local Discomfort from Local Acidosis from local accumulation of over production of metabolic acids (lactic acid);
  • Decreased Pathogen Resistance where disease organisms attack energy deplete cells residing in an acidic local environment;
  • Systemic Acidosis contribution when large percentage of metabolism is dependent on anaerobic glycolysis overwhelm acid transport;
  • Nutrient Depletion when the liver is forced to over-utilize gluconeogenisis / Cori Cycle;
  • pH Dysregulation – resulting from insufficient Carbon Dioxide Production limiting both Carbonic acid and bicarbonate availability.


1 ping

  1. […] This condition also disrupts glucose metabolism. Glucose use goes up because cells that don’t have enough oxygen use up to 19 times more glucose. This causes anaerobic lock. […]

Leave a Reply

Your email address will not be published.


Do NOT follow this link or you will be banned from the site!