Return to Cause

Cellular Hypoxia

Anaerobic metabolism occurs when the oxygen supply is unable to deliver enough oxygen to maintain aerobic energy production.  It is a supply versus demand system. See Cause for other factors.

Demand exceeds supply when either:

  1. Burst Demand occurs when there is a temporary demand increase that exceeds oxygen supply – under short term burst-exertion conditions;
  2. Cellular Hypoxia occurs when there is prolonged deficiency due to dysfunction of the oxygen delivery, or nutrient substrate required to maintain aerobic metabolism becomes durably deplete.

Sustained Cellular Hypoxia forces cells to operate long term anaerobic state, and often part of the process that triggers Anaerobic Lock condition.

A demand condition that overwhelms the primary and secondary system reserves may create durable cellular hypoxia by triggering inflammation in cells that line the vascular system, endothelium.   Cellular inflammation occurs when cellular sodium replaces potassium, resulting in enlarged regions of polarized water around sodium ions, which in turn compel the cell to absorb water inflate.

The inflation reduces the diameter of the capillary and limits or prevents passage of erythrocytes, red blood cells, through the capillary.  Limited erythrocytes, limit oxygen, which is needed to reverse the inflammation, so the condition remains fixed — and cellular hypoxia becomes durable.

Durable hypoxia occurs when a hypoxic or stress episode triggers other effects, capillary choke mechanism (Ardenne),  that inhibits the oxygen delivery process in an unrecoverable (under normal metabolism).  This effect is fully described in Chapter-1: Oxygen Multistep Therapy, Ardenne.

The durable nature of the capillary choke makes it a dominant factor in all fatigue and acid related dysfunctions because it creates a durable blockage to blood flow and oxygen delivery.

This author asserts it is a dominant cause of Anaerobic Lock.

    In most cases, cellular energy production is heavily dependent on anaerobic glycolysis for ongoing performance, resulting in:

    2 pings

    1. […] Oxygen Delivery decreases as as your body stays in a prolonged panic. Did you ever notice your first reflex upon being startled is to stop breathing? Count your breaths over 5 minutes – optimal is about 16 per minute. If you breathe 14 or less times per minute, stress has shifted your metabolism enough to chage your respiratory pattern. You are not producing enough CO2 to trigger respiration – and your body is running on more glucose and less oxygen than optimal. Cellular Hypoxia Page. […]

    2. […] started to make sense… The skin on my feet that grew in response to hypoxic inflammation.  Stress triggered inflammation, that caused my skin to grow fast and thick with poor quality. […]

    Leave a Reply

    Your email address will not be published.