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Cellular Hypoxia

Anaer­o­bic metab­o­lism occurs when the oxy­gen sup­ply is unable to deliv­er enough oxy­gen to main­tain aer­o­bic ener­gy pro­duc­tion.  It is a sup­ply ver­sus demand sys­tem. See Cause for oth­er fac­tors.

Demand exceeds sup­ply when either:

  1. Burst Demand occurs when there is a tem­po­rary demand increase that exceeds oxy­gen sup­ply — under short term burst-exer­tion con­di­tions;
  2. Cel­lu­lar Hypox­ia occurs when there is pro­longed defi­cien­cy due to dys­func­tion of the oxy­gen deliv­ery, or nutri­ent sub­strate required to main­tain aer­o­bic metab­o­lism becomes durably deplete.

Sus­tained Cel­lu­lar Hypox­ia forces cells to oper­ate long term anaer­o­bic state, and often part of the process that trig­gers Anaer­o­bic Lock con­di­tion.

A demand con­di­tion that over­whelms the pri­ma­ry and sec­ondary sys­tem reserves may cre­ate durable cel­lu­lar hypox­ia by trig­ger­ing inflam­ma­tion in cells that line the vas­cu­lar sys­tem, endothe­li­um.   Cel­lu­lar inflam­ma­tion occurs when cel­lu­lar sodi­um replaces potas­si­um, result­ing in enlarged regions of polar­ized water around sodi­um ions, which in turn com­pel the cell to absorb water inflate.

The infla­tion reduces the diam­e­ter of the cap­il­lary and lim­its or pre­vents pas­sage of ery­thro­cytes, red blood cells, through the cap­il­lary.  Lim­it­ed ery­thro­cytes, lim­it oxy­gen, which is need­ed to reverse the inflam­ma­tion, so the con­di­tion remains fixed — and cel­lu­lar hypox­ia becomes durable.

Durable hypox­ia occurs when a hypox­ic or stress episode trig­gers oth­er effects, cap­il­lary choke mech­a­nism (Ardenne),  that inhibits the oxy­gen deliv­ery process in an unre­cov­er­able (under nor­mal metab­o­lism).  This effect is ful­ly described in Chapter‑1: Oxy­gen Mul­ti­step Ther­a­py, Ardenne.

The durable nature of the cap­il­lary choke makes it a dom­i­nant fac­tor in all fatigue and acid relat­ed dys­func­tions because it cre­ates a durable block­age to blood flow and oxy­gen deliv­ery.

This author asserts it is a dom­i­nant cause of Anaer­o­bic Lock.

    In most cas­es, cel­lu­lar ener­gy pro­duc­tion is heav­i­ly depen­dent on anaer­o­bic gly­col­y­sis for ongo­ing per­for­mance, result­ing in:

    
          
          
        

    2 pings

    1. […] Oxy­gen Deliv­ery decreas­es as as your body stays in a pro­longed pan­ic. Did you ever notice your first reflex upon being star­tled is to stop breath­ing? Count your breaths over 5 min­utes – opti­mal is about 16 per minute. If you breathe 14 or less times per minute, stress has shift­ed your metab­o­lism enough to chage your res­pi­ra­to­ry pat­tern. You are not pro­duc­ing enough CO2 to trig­ger res­pi­ra­tion – and your body is run­ning on more glu­cose and less oxy­gen than opti­mal. Cel­lu­lar Hypox­ia Page. […]

    2. […] start­ed to make sense… The skin on my feet that grew in response to hypox­ic inflam­ma­tion.  Stress trig­gered inflam­ma­tion, that caused my skin to grow fast and thick with poor qual­i­ty. […]

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    Fatigue