Cause

This process mod­el of fatigue relies on engi­neer­ing prin­ci­ples based on mul­ti­le vari­ant sys­tems and Con­trol The­o­ry.

Fatigue is cel­lu­lar dys­func­tion that occurs when a body’s ener­gy sup­ply fails to meet ongo­ing demand result­ing in an absence of ener­gy, or tired­ness, as a result of dys­func­tion which affects inter­de­pen­dent aspects of cel­lu­lar ener­gy sys­tems.

Per­sis­tent fatigue usu­al­ly occurs with depen­dence of anaer­o­bic metab­o­lism replaces nor­mal use of aer­o­bic metab­o­lism:

  • Aer­o­bic Metab­o­lism is effi­cient and pro­duces Car­bon Diox­ide (38 ATP/Glucose) is 19 times more effi­cient;
  • Than anaer­o­bic metab­o­lism (2 ATP/Glucose) and does not pro­duce Car­bon Diox­ide.

Fatigue is the net effect of five con­cur­rent dys­func­tions which cre­ate a sta­ble equi­lib­ri­um of sus­tained defi­cien­cy of cel­lu­lar ener­gy.  Click on each of these links to for fur­ther expla­na­tion:

Func­tion­al­ly, cel­lu­lar fatigue is the result of one or more con­cur­rent caus­es:

  • Oxy­gen Defi­cien­cy — where the body is unable to deliv­er suf­fi­cient oxy­gen forc­ing the cells from aer­o­bic to anaer­o­bic ener­gy pro­duc­tion;
  • Deplet­ed Ener­gy Metabo­lites — where one or more nutri­ents required to main­tain cel­lu­lar aer­o­bic metab­o­lism fails to meet ongo­ing demand;
  • Tox­ic Inter­fer­ence — where one or more tox­ins cre­ate durable inter­fer­ence with cel­lu­lar ener­gy pro­duc­tion.

The rec­og­nized major­i­ty of cel­lu­lar ener­gy is pro­duced by the mito­chon­dria.
Here are addi­tion­al resources for fur­ther inves­ti­ga­tion:

Anaerobic Lock

Anaer­o­bic Lock — is a pro­longed meta­bol­ic con­di­tion where cells are forced to depend anaer­o­bic gly­col­y­sis for ener­gy pro­duc­tion.  See Cause for more fac­tors. This is usu­al­ly due to fac­tors which inhib­it oxy­gen deliv­ery to the cells includ­ing one or more dys­func­tions: hemo­to­log­i­cal cir­cu­la­to­ry oxy­gen trans­port Absence of oxy­gen forces cells to oper­ate and sur­vive …

Cellular Hypoxia

Anaer­o­bic metab­o­lism occurs when the oxy­gen sup­ply is unable to deliv­er enough oxy­gen to main­tain aer­o­bic ener­gy pro­duc­tion.  It is a sup­ply ver­sus demand sys­tem. See Cause for oth­er fac­tors. Demand exceeds sup­ply when either: Burst Demand occurs when there is a tem­po­rary demand increase that exceeds oxy­gen sup­ply — under short term burst-exer­­tion con­di­tions; …

Kreb’s Cycle

Fatigue occurs when the cel­lu­lar ener­gy the Mito­chon­dria ATP pro­duc­tion falls short of demand. This is nor­mal­ly due to a pro­longed break­down in the Aer­o­bic Krebs Cycle where the body is unable to deliv­er one or more required sub­strates to main­tain aer­o­bic metab­o­lism.

pH Dysregulation

Nor­mal oper­a­tion of the Kre­b’s Cycle pro­duces CO2 as a byprod­uct. When the Kre­b’s is inter­rupt­ed, the absence of CO2 cre­ates defi­cien­cy, and the defi­cien­cy inter­feres with both sides of the pH bal­ance sys­tems: CO2 res­pi­ra­tion via Car­bon­ic acid through the lungs is the dom­i­nant acid con­trol mech­a­nism; And Bicar­bon­ate through the kid­neys, is the …

Stable Equilibrium

This video describes sta­ble equi­lib­ri­um in a patho­log­i­cal state:

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Fatigue