pH Dysregulation

Nor­mal oper­a­tion of the Kre­b’s Cycle pro­duces CO2 as a byprod­uct. When the Kre­b’s is inter­rupt­ed, the absence of CO2 cre­ates defi­cien­cy, and the defi­cien­cy inter­feres with both sides of the pH bal­ance sys­tems:

• CO2 res­pi­ra­tion via Car­bon­ic acid through the lungs is the dom­i­nant acid con­trol mech­a­nism;
• And Bicar­bon­ate through the kid­neys, is the dom­i­nant alka­li con­trol mech­a­nism;
• See Cause for oth­er fac­tors.

A defi­cien­cy in CO2 pro­duc­tion can adverse­ly affect both both acid and alka­li bal­ance sys­tems.  This dys­func­tion nor­mal­ly occurs when tis­sues tend to anaer­o­bic metab­o­lism, result­ing in ele­vat­ed lac­tic acid relat­ed acids, H+, etc.

So there are mul­ti­ple con­cur­rent effects which cas­cade into suc­ces­sive stages of pH dys­reg­u­la­tion, depend­ing on the com­bi­na­tion of deplet­ed sub­strates:

1. Dis­rup­tion in res­pi­ra­to­ry pH from car­bon­ic & bicar­bon­ate bal­ance;
2. Ele­vat­ed lev­els in lac­tic acid relat­ed acids;
3. Com­pen­sato­ry deple­tion in sec­ondary oxi­da­tion agents which
   • Chlo­ride (Depletes Stom­ach Acid / HCL)
   • Chalco­gens: Sul­fur / Sele­ni­um
   • SO4 / NO3
4. B Vit­a­min Deple­tion;
5. Con­tri­bu­tion to the Bohr Effect which decreas­es oxy­gen trans­port; which fur­ther con­tributes to Cel­lu­lar Hypox­ia;
6. Appear­ance of mul­ti­ple res­pi­ra­to­ry imbal­ances which man­i­fest var­i­ous com­bi­na­tions of respiratory/metabolic acidosis/alkalosis.

This matrix of effects inter­feres with acid-base home­osta­sis and can result in diverse set of dys­reg­u­la­tion effects, depend­ing on the specifics reserves and deple­tions of sec­ondary acid-alka­li sub­strates.  See acid-base home­osta­sis.